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Croatian Medical Journal, Vol. 64 No. 2, 2023.

Original scientific paper

https://doi.org/10.3325/cmj.2023.64.75

Association between colonization of the respiratory tract with Ureaplasma species and bronchopulmonary dysplasia in newborns with extremely low gestational age: a retrospective study

Katja Gobec ; Faculty of Medicine Ljubljana, Ljubljana, Slovenia
Rebeka Mukenauer ; Faculty of Medicine Ljubljana, Ljubljana, Slovenia
Darja Keše ; Institute of Microbiology and Immunology, Ljubljana, Slovenia
Vanja Erčulj ; Rho Sigma Research & Statistics, Ljubljana, Slovenia
Štefan Grosek ; Department of Paediatric Surgery and Intensive Therapy, University Medical Centre Ljubljana, Ljubljana, Slovenia
Tina Perme ; Department of Perinatology University Medical Centre, Ljubljana, Slovenia *

* Corresponding author.

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Abstract

Aim To ascertain the incidence of respiratory tract colonization in extremely low gestational age newborns (ELGANs) with Ureaplasma parvum and Ureaplasma urealyticum and determine if there is a difference in the severity of
bronchopulmonary dysplasia (BPD) between ELGANs with
and without Ureaplasma species (spp) colonization.
Methods We reviewed the medical records of ELGANs 23
0/7–27 6/7 weeks of gestation, tested for U. parvum and
U. urealyticum in our Center from January 1, 2009 to December 31, 2019. Ureaplasma spp were identified with the
Mycofast Screening Revolution assay based on liquid broth
cultures or with polymerase chain reaction.
Results This study enrolled 196 preterm newborns. Fifty
(25.5%) newborns had Ureaplasma spp respiratory tract
colonization, with U. parvum being the predominant species. The incidence rate of respiratory tract colonization
with Ureaplasma spp slightly increased in the studied period. The incidence rate for 2019 was 16.2 per 100 infants.
BPD severity significantly correlated with Ureaplasma spp
colonization (P=0.041). After controlling for other risk factors for BPD in a regression model, preterm infants colonized with Ureaplasma spp had 4.32 times (95% confidence interval, CI 1.20-15.49) higher odds for developing
moderate-to-severe BPD.
Conclusions U. parvum and U. urealyticum could be associated with the development of BPD in ELGANs.

Keywords

Hrčak ID:

331516

URI

https://hrcak.srce.hr/331516

Publication date:

31.5.2023.

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