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Croatian Medical Journal, Vol. 64 No. 2, 2023.

Original scientific paper

https://doi.org/10.3325/cmj.2023.64.103

Epidemiology of vulvar cancer in Croatia

Irena Barišić orcid id orcid.org/0000-0003-0243-6767 ; Croatian Institute of Public Health, Zagreb, Croatia *
Petra Čukelj ; Croatian Institute of Public Health, Zagreb, Croatia
Ivana Brkić Biloš ; Croatian Institute of Public Health, Zagreb, Croatia
Mario Šekerija orcid id orcid.org/0000-0001-7508-1501 ; Croatian Institute of Public Health, Zagreb, Croatia

* Corresponding author.

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Abstract

Aim To assess the incidence and mortality trends of invasive
vulvar cancer in Croatia between 2001 and 2019/2020.
Methods The incidence data for the period 2001-2019
were obtained from the Croatian National Cancer Registry.
The number of deaths from invasive vulvar cancer by age
groups between 2001 and 2020 was obtained from the
Croatian Bureau of Statistics. Joinpoint regression analysis
was used to assess the trends and trend changes.
Results Joinpoint regression analysis of vulvar cancer incidence rate showed a non-significant average annual percent increase (APC) of 0.8 (95% confidence interval [CI] =
-0.3-2.0) during the whole period. There was also a non-significant increase in women under 60, with an average APC
of 1.0 (CI = -1.6-3.7) during the whole period; similar results
were obtained in women over 60 years of age (APC=0.9;
CI = -0.3-2.1). The average annual percent increase in vulvar
cancer mortality rate was 0.2% (CI = -1.0-1.5), with a similar
trend in women over 60 years of age (APC=0.1; CI=-1.3-
1.5). Mortality in women under 60 years of age was not assessed due to a very small number of deaths observed in
the study period.
Conclusion In the studied period, the incidence of invasive vulvar cancer in Croatia was stable. Age-standardized
rates (for all-ages, under 60, and over 60 years of age) increased, but the increase did not reach the level of statistical significance. The pattern in younger and older age
groups was the same. The mortality rates over the last decade were stable.

Keywords

Hrčak ID:

331519

URI

https://hrcak.srce.hr/331519

Publication date:

31.5.2023.

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