Original scientific paper
https://doi.org/10.3325/cmj.2023.64.383
Cognitive functioning is prognostic in patients with IDH1-wild type and MGMTunmethylated high-grade gliomas
Uroš Smrdel
; Division of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia
*
Andreja Cirila Škufca Smrdel
; Department of Psycho-Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Anja Podlesek
; Department of Psychology, Faculty of Arts, University of Ljubljana, Ljubljana, Slovenia
Marija Skoblar Vidmar
; Division of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Gregor Kos
; Division of Radiotherapy, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Jana Markovic
; Department of Psycho-Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Jana Jereb
; Department of Psycho-Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Jana Knific
; Department of Psycho-Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
Tina Rus
; Department of Psycho-Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia
* Corresponding author.
Abstract
Aim To investigate the prognostic factors of survival in patients with high-grade gliomas without isocitrate dehydrogenase-1 (IDH) mutation and O6
-methylguanine-DNA
methyltransferase (MGMT) promoter methylation.
Methods The study enrolled Slovenian patients with highgrade gliomas. Postoperatively, they completed a battery
of neuropsychological tests. Demographics and clinical
data were collected. The results of cognitive tests were
converted to standardized scores and dichotomized based
on impairment. A univariate Cox proportional hazard regression model was used to determine clinical predictors,
and a multivariate Cox model was used to determine the
prognostic value of cognitive test results. Kaplan-Meier
curves were constructed, and survival was compared with
the log rank test.
Results The study enrolled 49 patients with IDH wild-type,
MGMT-unmethylated high-grade gliomas. The median
time to progression was 9.92 months (7.25, 12.59) and the
overall median survival was 12.19 months (8.95, 15.4). Age
and the extent of surgery were significant prognostic factors for survival. After controlling for these factors, cognitive functioning in the domain of verbal fluency remained
a significant predictor of survival outcomes.
Conclusion Cognitive functioning in the domain of verbal
fluency was associated with overall survival independently of age and the extent of surgery. Cognitive functioning
could be an important stratifying tool in this group of patients lacking other predictors.
Keywords
Hrčak ID:
331881
URI
Publication date:
21.12.2023.
Visits: 160 *