Biochemia Medica, Vol. 19 No. 1, 2009.
Review article
Pleiotropic effects of ACE polymorphism
Syed K. Nawaz
; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
Shahida Hasnain
; Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
Abstract
Angiotensin converting enzyme (ACE) has vital role in normal functioning of the human body due to its direct involvement in the renin-angiotensin-aldosterone system (RAAS), kinin-kallikrein system, in vitro degradation of amyloid beta-peptide, GPIase (glycosylphosphatidylinositol, GPI) activity and in signal transduction. As ACE activity level is strongly influenced by ACE insertion/deletion (I/D) polymorphism, a huge body of data has been generated to elucidate the association of I/D polymorphism with cardiovascular and non cardiovascular diseases like diabetes, diabetic nephropathy, diabetic retinopathy, atherosclerosis, coronary heart diseases and stroke, hypertension, Alzheimer's disease, cancer and Parkinson's disease. This review will be limited to the effect of ACE I/D polymorphism on longevity considering the pathophysiology of several diseases.
Keywords
ACE polymorphism; longevity; early mortality; cardiovascular diseases
Hrčak ID:
32258
URI
Publication date:
5.2.2009.
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