Original scientific paper
The role of IGF-1 (CA)n polymorphism on peak bone mass attainment in males
Darko Kaštelan
; Department for endocrinology, Clinics for internal diseases, Clinical hospital centre Zagreb, Zagreb, Croatia
Zorana Grubić
; Centre for tissue typization, Clinical hospital centre Zagreb, Zagreb, Croatia
Katarina Štingl
; Centar za tipizaciju tkiva, KBC Zagreb, Zagreb, Hrvatska
Ivana Kraljević
; Zavod za endokrinologiju, Klinika za unutrašnje bolesti, KBC Zagreb, Zagreb, Hrvatska
Tina Dušek
; Zavod za endokrinologiju, Klinika za unutrašnje bolesti, KBC Zagreb, Zagreb, Hrvatska
Feđa Džubur
; Zavod za endokrinologiju, Klinika za unutrašnje bolesti, KBC Zagreb, Zagreb, Hrvatska
Zlatko Giljević
; Zavod za endokrinologiju, Klinika za unutrašnje bolesti, KBC Zagreb, Zagreb, Hrvatska
Vesna Kerhin-Brkljačić
; Centar za tipizaciju tkiva, KBC Zagreb, Zagreb, Hrvatska
Mirko Koršić
; Zavod za endokrinologiju, Klinika za unutrašnje bolesti, KBC Zagreb, Zagreb, Hrvatska
Abstract
Aim: Idiopathic osteoporosis in males is influenced predominantly by low peak bone mass as a feature under a strong genetic control. Among number of candidate genes, IGF-1 gene is of particular interest due to its important role in bone metabolism. It has been reported that IGF-1 citozin-adenin (CA)n polymorphism is related to serum IGF-1 concentration. Therefore, in the present study we examined the influence of certain IGF-1 (CA)n alleles on peak bone mass attainment in males.
Methods: Study sample consisted of 92 unrelated healthy male volunteers, aged 21-35. In each subject, lumba spine and proximal femur bone mineral density (BMD), bone turnover markers, 25-OHD and sex hormones levels were measured.
Results: IGF-1 (CA)18 allele (genotype 18+) were found to be �associated with low-lower BMD in all measured areas but the differences between analysed groups were not significant.
However, homozygotes (CA)18 had significantly lower femoral neck (P=0,03), trochanter (P=0,01) and total hip (P=0,04) BMD whereas differences in bone turnover markers, 25-OHD, free testosterone and estradiol concentrations were not significant.
Discussion: The results of the present study suggested possible negative effect of the IGF-1 (CA)18 allele on the peak bone mass attainment in males. However, for definitive conclusion about the role of this polymorphism in the pathogenesis of osteoporosis further studies in different populations and with larger number of participants are needed.
Keywords
bone mineral density; IGF-1 gene; males; osteoporosis; peak bone mass
Hrčak ID:
34703
URI
Publication date:
2.3.2009.
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