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Collegium antropologicum, Vol. 33 supplement 2 No. 2, 2009.

Pregledni rad

Urolithiasis and Osteoporosis: Clinical Relevance and Therapeutic Implications

Ines Bilić-Ćurčić ; Department for Mineral Metabolism, School of Medicine, University »Josip Juraj Strossmayer«, Osijek, Croatia
Jasminka Milas-Ahić ; Department for Mineral Metabolism, School of Medicine, University »Josip Juraj Strossmayer«, Osijek, Croatia
Martina Smolić ; Department for Mineral Metabolism, School of Medicine, University »Josip Juraj Strossmayer«, Osijek, Croatia
Robert Smolić ; Department for Mineral Metabolism, School of Medicine, University »Josip Juraj Strossmayer«, Osijek, Croatia
Ivan Mihaljević ; Department for Nuclear Medicine, School of Medicine, University »Josip Juraj Strossmayer«, Osijek, Croatia
Sandra Tucak-Zorić ; City Office for Energetics Development, Environmental Protection and Sustainable Development, Zagreb, Croatia

Puni tekst: engleski pdf 64 Kb

str. 189-192

preuzimanja: 579

citiraj

Sažetak

Several clinical and epidemiological studies revealed increased bone turnover and lower bone mass in patients with urolithiasis. Bone mass loss is particularly evident in idiopathic calcium stone formers. However, pathogenetic mechanisms and factors implicated in bone loss in these patients are still unknown. Dietary calcium restriction, increased intake of salt and animal proteins, vitamin D receptor polymorphisms are likely risk factors, while role of inflammatory cytokines, osteopontin and prostaglandin mediated bone resorption is yet to be determined. Regarding treatment and prevention, it has been proven that calcium supplements and high calcium diet with the addition of potassium alkali have an important role in prevention and treatment of both, urolithiasis and osteoporosis. Thiazide diuretics reduce hypercalciuria in renal tubules, and in addition promote osteoblast differentiation. Finally, bisphosphonates, a commonly used drugs in treatement of osteoporosis, show the potential to inhibit calcium stone formation, whereas a possible protective effect of antioxidants in bone loss and renal injurie needs to be investigated further.

Ključne riječi

osteporosis; urolithiasis; bone loss; prevention; treatment

Hrčak ID:

51706

URI

https://hrcak.srce.hr/51706

Datum izdavanja:

20.12.2009.

Posjeta: 1.393 *