Review article
https://doi.org/10.2478/10004-1254-62-2011-2107
Cholinesterases: Structure, Role, and Inhibition
Anita Bosak
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Maja Katalinić
orcid.org/0000-0001-7043-4291
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Zrinka Kovarik
; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
Abstract
Enzymes acetylcholinesterase (AChE; E.C. 3.1.1.7) and butyrylcholinesterase (BChE; E.C. 3.1.1.8) have intensively been investigated in biomedicine and toxicology due to important role in organisms. Even if structurally homologous, they differ in catalytic activity, specificity, for substrates, and selectivity in binding to many ligands. This paper compiles the results of research on cholinesterases and their interactions with ligands and inhibitors, and identifies amino acids of active sites involved in these interactions.
Keywords
acetylcholinesterase; butyrylcholinesterase; inhibitors; selectivity; stereoselectivity
Hrčak ID:
69311
URI
Publication date:
17.6.2011.
Visits: 5.364 *