Original scientific paper

https://doi.org/10.2478/v10007-011-0025-3

Design and evaluation of a bioadhesive film for transdermal delivery of propranolol hydrochloride

BAZIGHA K. ABDUL RASOOL ; Department of Pharmaceutics and Pharmacy Practice, Dubai Pharmacy College, Dubai, UAE
UDAY S. AZIZ ; Department of Pharmaceutics, College of Pharmacy, University of Basra, Basra, Iraq
OMAR SARHEED ; Department of Pharmaceutics, RAK College of Pharmaceutical Sciences, Ras Al-Khaimah Medical and Health Sciences University, Ras Al-Khaimah, UAE
ALAA A. ABDUL RASOOL ; College of Pharmacy, University of Bagdad, Bagdad, Iraq

Abstract

The objective of the study was to develop a suitable transdermal delivery system for propranolol hydrochloride (PPL) via employing chitosan as a film former. Drug concentration uniformity, thickness, moisture uptake capacity and skin bioadhesion of the films were characterized. The effects of chitosan and PPL concentration and different penetration enhancers on the release and permeation profiles from the films were investigated. Skin irritation of the candidate film was evaluated.
Chitosan film (PPL 2 mg cm2, chitosan 2 % m/m, cineol 10 %, m/m) was found non-irritant and achieved 88.2 % release after 8 hours in phosphate buffer. Significant high (p < 0.001) permeation of PPL through rat skin was obtained using this film compared to the film without enhancer (about 8 times enhancement factor), making it a promising transdermal delivery system for PPL.

Keywords

transdermal delivery; propranolol hydrochloride; chitosan film; enhancers

Hrčak ID:

69434

URI

https://hrcak.srce.hr/69434

Publication date:

1.9.2011.

Article data in other languages: croatian

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