Cardiologia Croatica, Vol. 6 No. 5-6, 2011.
Professional paper
Fixed combination of felodipine and metoprolol in treatment of hypertension.
Darko Počanić
orcid.org/0000-0003-3257-110X
; Clinical Hospital Merkur, Zagreb, Croatia
Abstract
The therapy with combination of felodipine
and metoprolol in treatment of hypertension results in satisfactory
effect with hypertensive patients on lowering the values of
systolic and diastolic blood pressure (BP). This effect is sustained
during the period over two years, while lowering of systolic
and diastolic BP results in reduction of total cardiovascular
complications: reduction of incidence of stroke for one
third of patients and myocardial infarction for one sixth of patients.
This fixed combination is applicable with patients that
did not manage to regulate BP by using some other specific
antihypertensive drugs, achieving sustained lowering of BP in
a 24-hour period. There are fewer side-effects associated with
this therapy than with the fixed combinations of antihypertensive
drugs used so far, since there are no negative metabolic
effects and therefore it may be applied in high risk patients
with metabolic syndrome and diabetes. The application of the
fixed combination of felodipine and metoprolol may achieve
the set targets related with lowering of BP and reducing cardiovascular
risk efficiently in 70-89% patients. Both felodipine
and metoprolol are individually applied in treatment of coronary
heart disease whereas this combination may lead to coronary
protection.
Keywords
felodipine; metoprolol; hypertension
Hrčak ID:
71479
URI
Publication date:
16.6.2011.
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