Medicina Fluminensis, Vol. 47 No. 3, 2011.
Review article
Cutaneous neurobiology: modern concept and perspectives in the treatment of skin diseases
Ines Brajac
; Klinika za dermatovenerologiju, KBC Rijeka, Rijeka
Teo Manestar
; Klinika za dermatovenerologiju, KBC Rijeka, Rijeka
Danijela Malnar
; Zavod za anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Abstract
The skin is the most densely innervated organ in the body and there is a close relationship
between the skin and the nervous system. Monodirectional and/or bidirectional pathways exist in which the central and peripheral nervous system, endocrine and immune system, and almost all skin cells are involved. The interaction between peripheral nerves and immune system is mediated by different types of cutaneous nerve fibers which release neuromediators
and activate specific receptors on target cells in the skin such as keratinocytes, mast cells, Langerhans cells, microvascular endothelial cells, fibroblasts, and infiltrating immune
cells. These interactions influence a variety of physiologic and pathophysiologic functions
including cellular development, growth, differentiation, immunity, vasoregulation, leukocyte
recruitment, pruritus, and wound healing. Information is emerging about the factors involved in these immunomodulatory mechanisms. Recent findings have established a modern
concept of cutaneous neurobiology.
Keywords
nervous system; neurobiology; neuropeptides; skin
Hrčak ID:
71754
URI
Publication date:
5.9.2011.
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