Professional paper

EXANTHEMA MEDICAMENTOSUM AS A SIDE EFFECT OF PROMAZINE

Davor Lasić orcid.org/0000-0001-7571-0291 ; University Psychiatric Clinic, Clinical Hospital Centre Split, Croatia
Marija Žuljan Cvitanović ; University Psychiatric Clinic, Clinical Hospital Centre Split, Croatia
Boran Uglešić ; University Psychiatric Clinic, Clinical Hospital Centre Split, Croatia
Vitomir Višić ; Psychiatric Hospital Ugljan, Croatia
Ivana Hlevnjak ; Clinic of Dermatology and Venerology, Clinical Hospital Centre Split, Croatia

Abstract

Dermatological side effects of psychopharmacological drugs are fortunately not so often. They are mostly presented in the group
of mood stabilizers and antiepileptic drugs, particularly the carbamazepine and lamotrigine, and can be manifested through the
Stevens Johnson syndrome, Toxic Epidermal Necrolysis (TEN)/Lyell’s syndrome with about 30% lethality. According to the
literature the group of phenothiazines is the category of drugs with rare appearances of skin reactions. Promazine, aliphatic
phenothiazines antipsychotic, including less frequent side effects in the leaflet states increased skin sensitivity to sun, skin rashassociated
with contact dermatitis, allergic reactions, cholestatic icterus. The only reported dermatological side effect of promazine
is its metabolites deposition in the cornea. Analyzing the e-data basis we have not found references connecting the Exanthema
medicamentosum as a side effect of promazine. A forty-two years old female patient was admitted to the Dermatological Clinic
because of suspected exanthema, undoubtedly caused by promazine as a medication for Sy. Borderline.

Keywords

promazine; exanthema medicamentosum

Hrčak ID:

76818

URI

https://hrcak.srce.hr/76818

Publication date:

30.6.2011.

Visits: 1.569 *