Original scientific paper

Effect of ketoprofen co-administration or febrile state on pharmacokinetic of cefepime in sheep.

Nimesh N. Patel ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry Anand Agricultural University, Anand, India
Hiren B. Patel ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry Anand Agricultural University, Anand, India
Shital D. Patel ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry Anand Agricultural University, Anand, India
Jatin H. Patel ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari, India
Shailesh K. Bhavsar ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Navsari Agricultural University, Navsari, India
Aswin M. Thaker ; Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry Anand Agricultural University, Anand, India

Abstract

The pharmacokinetics of cefepime (20 mg/kg) were studied following intramuscular administration of cefepime alone, co-administered with ketoprofen (3 mg/kg) and in a febrile state (Escherichia coli LPS induced) in sheep. The concentration of cefepime in the serum was detected by High Performance Liquid Chromatography. Following single dose intravenous administration of cefepime, elimination half life (2.50 ± 0.05 h), the area under the curve (143.48± 7.36 μg.h/mL), body clearance (0.14 ± 0.01 L/h/kg) and volume of distribution (0.51 ± 0.03 L/kg) were determined. Following a single dose intramuscular administration of cefepime alone, peak serum concentration (28.76 ± 0.54 μg/mL) was obtained at 0.75 h. The absorption half life (t1/2Kα), volume of distribution (Vdarea), total body clearance (ClB) and elimination half life (t1/2β) of cefepime were 0.16 ± 0.01 h, 1.02 ± 0.08 L/kg, 0.13 ± 0.01 L/h/kg and 5.31 ± 0.23 h, respectively. Following co-administration of ketoprofen (30.74 ± 1.22 μg/mL) and in a febrile condition, a higher peak serum concentration of cefepime (39.68 ± 1.13 μg/mL) was observed at 0.75 h and 1 h, respectively. However, no significant changes were reported in other pharmacokinetic parameters following co administration of cefepime with ketoprofen. In a febrile state, absorption half life, area under the curve and bioavailability were significantly increased while the volume of distribution and clearance of cefepime were significantly decreased following intramuscular administration. Cefepime pharmacokinetic data (20 mg/kg) generated from the present study suggest that the drug may be administered with ketoprofen, and in febrile conditions in sheep, the drug may be given intramuscularly at 24 h intervals to combat susceptible bacterial infections.

Keywords

pharmacokinetic; cefepime; ketoprofen; fever; sheep

Hrčak ID:

86313

URI

https://hrcak.srce.hr/86313

Publication date:

11.9.2012.

Article data in other languages: croatian

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