Editorial

PATHOPHYSIOLOGICAL MECHANISMS OF ALLERGIC DISEASE OCCURRENCE AND TREATMENT

BRANKO PEVEC ; Department of Clinical Immunology, Pulmology and Rheumatology,Sveti Duh University Hospital, Zagreb, Croatia
MIRA RADULOVIĆ PEVEC ; Department of Clinical Immunology, Pulmology and Rheumatology,Sveti Duh University Hospital, Zagreb, Croatia
ASJA STIPIĆ MARKOVIĆ ; Department of Clinical Immunology, Pulmology and Rheumatology,Sveti Duh University Hospital, Zagreb, Croatia
IRENA BATIŠTA ; Immunological Laboratory, Sveti Duh University Hospital, Zagreb, Croatia

Abstract

Why the exposure to the harmless and ubiquitous environmental substances causes inappropriately strong reactions of the immune
system clinically manifested as allergies in some people, and how repeated exposures to the same substances during the
specific immunotherapy divert immunologic reactivity, are so far only partially answered questions. The events that occur during the allergic inflammatory response are relatively well-known, as are the major operative mechanisms through which the specific
immunotherapy, the only causative treatment method, change that response. Nevertheless, everyday new findings are completing
the puzzle and our understanding of these complex processes. The aim of this paper was to review the up-to-date known mechanisms of allergic disease occurrence and treatment, with regard to the key role of T cells in these processes.

Keywords

allergy; specific immunotherapy; T cells; Treg; Th1; Th2; T-BET; GATA-3; FOXP3

Hrčak ID:

89626

URI

https://hrcak.srce.hr/89626

Publication date:

30.10.2012.

Article data in other languages: croatian

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