Review article
https://doi.org/10.2478/10004-1254-64-2013-2294
Antioxidants in Organophosphorus Compounds Poisoning
Syed M Nurulain
; Department of Pharmacology and Therapeutic, Faculty of Medicine and Health Sciences, UAE University, AlAin UAE
Peter Szegi
; Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
Kornèlia Tekes
; Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
Syed NH Naqvi
; Department of Pharmacology Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan
Abstract
Oxidative stress has recently been implicated as a factor in the mortality and morbidity induced by organophosphorus (OP) compound poisoning. An overwhelming number of research papers are based on studying at the cellular and organ level. Such studies have concluded that antioxidants can be used as an adjunct compound in the treatment of both chronic as well as acute OP poisoning. Still, the role of antioxidants in reducing the mortality and morbidity induced by OP compounds has scarcely been verified, as well as their role as adjunct treatment compounds for both structurally and functionally different OP compounds. The present review of the literature was undertaken to establish the role of antioxidants in survival studies following acute exposure to OP compounds. The review found no substantial evidence that antioxidants demonstrate any positive effect following extremely toxic poisoning. However, for a more comprehensive and rational conclusion, further research needs to be conducted.
Keywords
acute poisoning; oxidative stress; survival study
Hrčak ID:
98700
URI
Publication date:
20.3.2013.
Visits: 4.510 *