Original scientific paper

Characterization of 2-D Proteome Maps Based on the Nearest Neighborhoods of Spots

Milan Randić ; National Institute of Chemistry, P.O. Box 3430, 1001 Ljubljana, Slovenia and Department of Mathematics and Computer Science Drake University, Des Moines, IA 50311, USA
Nella Lerš ; The Ruđer Bošković Institute, P.O. Box 180, HR-10002 Zagreb, Croatia
Dejan Plavšić ; The Ruđer Bošković Institute, P.O. Box 180, HR-10002 Zagreb, Croatia
Subhash C. Basak ; Natural Resources Research Institute, University of Minnesota at Duluth, 5013 Miller Trunk Highway, Duluth, MN 55811, USA

Abstract

A novel approach to the construction of invariants for characterization of 2-D maps, such as 2-D proteome maps, 2-D NMR spectral maps, etc., is put forward. The approach is based on consideration of the neighborhood of points (spots) of the map and it is sufficiently flexible to allow one to vary not only the number of nearest neighbor spots used in characterization of a map but also the density of information on the relative distance of the selected map points. The method is illustrated with a Coomassie brilliant blue stained 2-D gel electrophoresis pattern of the Fisher F344 rat liver proteome.

Keywords

proteome; 2-D proteome map; map invariant; neighborhood graph

Hrčak ID:

102726

URI

https://hrcak.srce.hr/102726

Publication date:

31.5.2004.

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