Review article

Oral Lichen Ruber - I Etiology and Pathogenesis

Dolores Biočina-Lukenda

Abstract

Oral lichen rubber (OLR) is a frequentchronic mucocutane autoimmune disease in the population. OLR mostly affects middleaged and older individuals. Women make 2/3 of patients. Etiology of the disease is still unexplained, with numerous etiologic factors being the possible cause of the onset of this disease. Genetic predispositions are the most frequently quoted cause together with the local use of specific dental materials, systematic use of specific drugs in basic disease therapy, infection, results of autoimmune disease, and disorders such as diabetes mellitus, chronic liver disease, hypertension, and emotional stress. All the above mentioned factors can induce a sequence of immunologic events and reflect on the immunological state of the patient.Thus, induced sequence of immunological events is based on cell mediated immunity, including interactivity of oral epithelium cells and the immunological cell mediated by activity of adhesion molecules, and is behind the pathogenetic mechanism of OLR.

Keywords

oral lichen ruber; etiologic factors; pathogenetic mechanisms

Hrčak ID:

10358

URI

https://hrcak.srce.hr/10358

Publication date:

15.12.2002.

Article data in other languages: croatian

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