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Review article

Glucocorticoid-Induced Osteoporosis

Božidar Ćurković


Full text: croatian pdf 62 Kb

page 19-24

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Abstract

Glucocorticoids are the most common cause of drug-induced osteoporosis. Given the widespread use of oral glucocorticoids in the treatment of autoimmune, pulmonary, gastrointestinal disorders and organ transplantation, attention to glucocorticoid-induced osteoporosis has substantially increased. Bone loss occurs rapidly in the first few months of glucocorticoid therapy. Trabecular bone is affected more than cortical bone. Glucocorticoid treatment is associated with a substantially increased risk of fractures, particularly hip and vertebral fractures. The skeletal effects of glucocorticoids are both dose- and durationdependent. The patophysiology of glucocorticoid-induced osteoporosis is a complex process, several mechanisms are proposed but not yet fully highlighted. Despite several evidence-based guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis and the availability of effective therapeutic options, the proportion of individuals with appropriate evaluation and treatment remains relatively low.

Keywords

drug-induced osteoporosis; osteoclastogenesis; osteoporosis management; pathophysiology; risk of fractures

Hrčak ID:

10610

URI

https://hrcak.srce.hr/10610

Publication date:

16.3.2007.

Article data in other languages: croatian

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