Review article

Vaccination in chronic autoimmune and inflammatory rheumatic diseases

Daniela Marasović Krstulović ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia
Dušanka Martinović Kaliterna ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia

Abstract

Vaccine preventable infections occur more often in patients with autoimmune and chronic rheumatic diseases when compared to the general population. Most vaccines are immunogenic, efficacious and safe in those patients, even with immunosuppressive treatment, excluding rituximab. Live attenuated vaccines should be avoided in patients receiving long-term immunosuppressive therapy. The occurrence of adverse events and autoimmune phenomena is almost the same in vaccinated patients with rheumatic diseases and in vaccinated healthy individuals. A deeper research is needed regarding safety of vaccination and the influence of new immunomodulating drugs on efficacy of vaccination since the studies that were undertaken so far are retrospective or performed on small cohorts of patients. Evidence-based recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases developed by European League Against Rheumatism (EULAR) will help rheumatologists in making a decision about vaccinating their patients.

Keywords

vaccination; prevention; rheumatic diseases; immunomodulating drugs

Hrčak ID:

124381

URI

https://hrcak.srce.hr/124381

Publication date:

1.4.2012.

Article data in other languages: croatian

Visits: 7.909 *