Conference paper

Strontium ranelate’s (Osseor®) dual mode of action: increasing bone mass and decreasing bone resorption

Dušanka Martinović Kaliterna ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Split, Split, Croatia

Abstract

Strontium ranelate has unique dual mode of action on bone remodeling through increased bone formation and decreased bone resorption. As a consequence, there is increased bone mass and bone strength, leading to reduced number of vertebral and nonvertebral fractures. Although strontium bone distribution is heterogeneous, higher concentrations of strontium are found in younger bones. Long term treatment with strontium ranelate does not lead to any change in bone mineral distribution, mineral composition or crystal stability, nor is strontium accumulated in bone.

Keywords

strontium ranelate; bone mass; bone resorption; minerals

Hrčak ID:

125251

URI

https://hrcak.srce.hr/125251

Publication date:

17.10.2008.

Article data in other languages: croatian

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