Professional paper

Proposal for anti-TNFα therapy in adult patients with rheumatoid arthritis

Božidar Ćurković ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Đurđica Babić-Naglić ; Clinic for Rheumatic Diseases and Rehabilitation, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Jadranka Morović-Vergles ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital “Dubrava”, Zagreb, Croatia
Branimir Anić ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Simeon Grazio ; Clinic for Rheumatology, Physical Medicine and Rehabilitation, Clinical Hospital “Sestre milosrdnice”, Zagreb, Croatia

Abstract

Rheumatoid arthritis is a chronic, inflammatory disease with the prevalence about 1 %. Rheumatoid arthritis is caracterized with synovitis, erosive changes of the joints, pain and functional deficit. Etiology is unknown. In the pathogenesis of rheumatoid arthritis the key role have proinflammatory citokines, particularly, tumour necrosis factor (TNFα). TNFα blockers have documented, fast and continuous efficacy with generally well accepted safety profile. Nowdays, TNFα antagonists are established drugs in early and late phase of rheumatoid arthritis. Prescription of TNFα antago­nists is controlled, according local restrictions, regarding high costs of the therapy. On behalf of Croatian Society for Rheumatology we propose recommendations for the TNFα antagonist therapy in rheumatoid arthritis.

Keywords

rheumatoid arthritis; TNF inhibitors; recommendations

Hrčak ID:

125317

URI

https://hrcak.srce.hr/125317

Publication date:

1.7.2008.

Article data in other languages: croatian

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