Short communication, Note

https://doi.org/10.2478/v10007-007-0029-1

Synthesis and brain antihypoxic activity of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid

JAVOR MITKOV
JAVOR MITKOV
NIKOLAI DANCHEV
IRINA NIKOLOVA
ALEXANDER ZLATKOV

Abstract

The synthesis of some aliphatic and arylaliphatic amides of caffeine-8-thioglycolic acid was studied. The structures of synthesized compounds were proved by microanalyses, IR- and 1H NMR data. Values of acute p.o. and i.p. toxicity in mice show lower toxicity compared to caffeine. Declines in spontaneous locomotor activity support the idea of depressive CNS activity of the compounds. Two compounds exhibited brain antihypoxic activity (5a and 5b against haemic and circulatory hypoxia, respectively).

Keywords

caffeine-8-thioglycolic acid; aliphatic and arylaliphatic amides; brain antihypoxic activity; acute toxicity

Hrčak ID:

12064

URI

https://hrcak.srce.hr/12064

Publication date:

1.9.2007.

Article data in other languages: croatian

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