Reumatizam, Vol. 53 No. 2, 2006.
Review article
Hematological abnormalities in rheumatic diseases
Ivo Radman
; Department for Hematology, Clinic for Internal Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Abstract
Haematological abnormalities are present in 25-50% patients with rheumatic diseases. The most common finding is anaemia of chronic disease which is driven by inflammatory cytokines. Hepcidin plays key role in iron homeostasis. It reduces iron absorption from duodenum and iron release from reticuloendothelial cells. Anaemia of chronic disease could be successfully treated by recombinant erythropoietin in combination with iron supplementation. Various abnormalities can be observed in the leukocyte and platelets counts. Other haematological disturbances are considered as part of autoimmune disease. Prolonged antigen stimulation can induce lymphomagenesis and lymphoma incidence in patients with rheumatic diseases is 5 to 6-fold increased compared to normal population.
Keywords
rheumatic diseases; haematological abnormalities; anaemia of chronic disease; leukopenia; thrombocytopenia
Hrčak ID:
125824
URI
Publication date:
20.10.2006.
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