Conference paper

Nonsteroidal antirheumatics and the kidney

Krešimir Galešić ; Department for Nephrology, Clinic for Internal Medicine, Clinical Hospital “Dubrava”, Zagreb, Croatia
Jadranka Morović-Vergles ; Department for Clinical Immunology and Rheumatology, Clinic for Internal Medicine, Clinical Hospital “Dubrava”, Zagreb, Croatia
Bojan Jelaković ; Department for Nephrology and Hypertension, Clinic for Internal Medicine, Clinical Hospital Centre Zagreb, Zagreb, Croatia

Abstract

The renal side effects of nonsteroidal anti-inflammatory drugs are very often and could be seen in 5% of patients who are treated with this drugs.
These side effects could be separated in 5 clinical syndromes: 1. acute renal failure, 2. acute interstitial nephritis with nephrotic syndrome, 3. electrolyte and fluid disorders, 4. hypertension and 5. analgesic nephropathy. There are a lot data in the literature which suggest that selective COX-2 inhibitors (rofecoxib and celecoxib) produce the similar effects on the kidney as traditional nonsteroidal anti-inflammatory drugs (inhibitors of COX-1 and COX-2).

Keywords

nonsteroidal anti-inflammatory drugs; traditional nonsteroidal anti-inflammatory drugs; selective COX-2 inhibitors; nefrotoxicity

Hrčak ID:

125922

URI

https://hrcak.srce.hr/125922

Publication date:

14.10.2005.

Article data in other languages: croatian

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