Veterinary Archives, Vol. 84 No. 6, 2014.
Original scientific paper
Oxidative stress, hematobiochemical parameters, trace elements and vitamins in dogs with zinc responsive dermatosis.
Shafayat A. Beigh
; Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shuhama, Alasteng- Jammu, India
Jaswinder S. Soodan
; Department of Teaching Veterinary Clinical Complex, Faculty of Veterinary Science and Animal Husbandry, Shere-e-Kashmir University of Agricultural Sciences and Technology of Jammu R. S. Pura Jammu ( J& K), India
Salik Nazki
; Division of Veterinary Microbiology and Immunology, Faculty of Veterinary Science and Animal Husbandary, Shere-e-Kashmir University of Agricultural Sciences and Technology of Kahmir, Shuhama, Alasteng (J & K), India
Adil M. Khan
; Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary and Animal Science University, Ludhiana, Punjab, India
Abstract
The aim of this study was to examine the hemato-biochemical alterations and evaluate the oxidative stress indices in the blood of dogs with zinc responsive dermatosis. The study included 9 dogs with clinically established diagnosis of zinc responsive dermatosis and 6 dogs as a healthy control. The clinical disease was characterized by alopecia, erythema, hyperkeratotic foot pads and scaling around the eyes, chin, eyes, head and legs. The MDA levels were significantly (P<0.01) higher, whereas superoxide dismutase and catalase activity were significantly (P<0.01) lower when compared to healthy control dogs. Hematology revealed significant neutrophilia and lymphopenia, along with anemia. Biochemical examination revealed a significant (P<0.05) decrease in albumin, A:G ratio and glucose levels, and a significant increase (P<0.05) in globulin level. Plasma zinc, vitamin A and C were significantly decreased, however copper levels were increased. In conclusion, zinc responsive dermatosis is accompanied by oxidative stress and anemia, and affected animals are susceptible to infection.
Keywords
biochemical; dermatitis; hematology; hyperkeratotic; oxidative stress; zinc
Hrčak ID:
130369
URI
Publication date:
5.12.2014.
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