Reumatizam, Vol. 61 No. 1, 2014.
Review article
The significance of innate immunity in juvenile idiopathic arthritis
Dubravka Bobek
; Center for Physical and Rehabilitation Medicine, Clinical Hospital Dubrava, Zagreb, Croatia
Marija Jelušić
; Clinic for Pediatrics of the School of Medicine, University of Zagreb, Clinical Hospital Centre Zagreb, Zagreb, Croatia
Abstract
For years it was thought that the disorder of adaptive immunity is critical in the pathogenesis of juvenile idiopathic arthritis (JIA). However, the results of recent studies emphasize the importance of innate immunity and especially the role of alarmins, a group of multifunctional proteins that are released into the intercellular space during tissue injury or inflammation, mobilizing and activating the cells of innate immunity. These data indicate that inflammation triggered by alarmins plays a role in the pathogenesis of JIA. Furthermore, alarmins may serve as inflammatory markers and targets of therapy.
Keywords
JIA; innate immunity; alarmins
Hrčak ID:
137775
URI
Publication date:
30.9.2014.
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