Original scientific paper

Frequency of HLA-DRB1-DQA1-DQB1 haplotypes in psoriatics with positive and negative family history

Marija Kaštelan ; Klinika za dermatovenerologiju, KBC Rijeka, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Larisa Prpić Massari ; Klinika za dermatovenerologiju, KBC Rijeka, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Ines Brajac ; Klinika za dermatovenerologiju, KBC Rijeka, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sandra Peternel ; Klinika za dermatovenerologiju, KBC Rijeka, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Esma Čečuk Jeličić ; Centar za tipizaciju tkiva, Klinički bolnički centar Zagreb
Zorana Grubić ; Centar za tipizaciju tkiva, Klinički bolnički centar Zagreb
Andrija Kaštelan ; Centar za tipizaciju tkiva, Klinički bolnički centar Zagreb

Abstract

Aim: To analyze the distribution of HLA-DRB1-DQA1-DQB1 haplotypes as well as the extended haplotype Cw*0602-B57-DRB1*07 DQA1*0201-DQB1*0201 in patients with positive and negative family history of psoriasis. Patients and methods: The association of HLA genes classes I and II with psoriasis has been studied in 118 patients with chronic stable psoriasis. The frequency of HLA haplotypes was analyzed by means of serology and hybridization with specific oligonucleotide probes. Results: The group with positive family history showed a significant association with DRB1*07-DQA1*0201-DQB1*0201 and DRB1*07- DQA1*0201-DQB1*0303 as well as with the extended haplotype Cw6-B57-DRB1*0701- DQA1*0201-DQB1*0201 (P = 0,004). The frequency of extended haplotype in the group with negative family history was similar to the control group. Conclusion: Psoriatics with positive family history show stronger association with susceptible

Keywords

HLA genes; HLA haplotype; psoriasis

Hrčak ID:

139474

URI

https://hrcak.srce.hr/139474

Publication date:

1.6.2015.

Article data in other languages: croatian

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