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Myeloid Sarcoma of the Skin in a Patient with Myelodysplastic Syndrome
Darko Antic
Andrija Bogdanovic
Maja Perunicic Jovanovic
Jelica Jovanovic
Ivo Elezovic
Abstract
ABSTRACT We report the case of a 76-year-old woman who presented with asymptomatic extensive erythematous. Firm plaques were noted over the right cheek. Complete blood count was normal, as was a peripheral smear. An excision biopsy taken from the cheek showed infiltration of the dermis and hypodermis with atypical cells which were strongly positive for human leukocyte antigen (HLA-DR) and lysozyme and were moderately myeloperoxidase (MPO) enzyme. The results of immunohistochemical staining for CD34, CD117, CD3, CD4, CD8, CD20, CD23, CD56, and ALK-1 were negative. Bone marrow analysis indicated myelodysplastic syndrome RAEB 1 while cytogenetic finding showed tetrasomy 8. It was recommended that the patient undergo local radiotherapy of skin lesions, but she refused and was lost to follow-up.
KEY WORDS: skin; myeloid sarcoma; myelodysplastic syndrome
Keywords
Hrčak ID:
142143
URI
Publication date:
21.7.2015.
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