Acta Pharmaceutica, Vol. 66 No. 1, 2016.
Short communication, Note
https://doi.org/10.1515/acph-2016-0010
Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts
ALEŠ FRANC
; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
JAN MUSELÍK
; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic; Masaryk Memorial Cancer Institute, Brno, Czech Republic
ROMAN GONĚC
; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
DAVID VETCHÝ
; Department of Pharmaceutics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic
Abstract
Substances in the form of weak acid salts have been found to be problematic for dissolution testing. Their absorption can start only after they are turned into the form of an acid following the gastric passage although they were administered in the form of a salt. Due to poor solubility, they cannot be tested in acidic gastric environment for a biased dissolution profile. The biphasic dissolution method is promising for overcoming this obstacle. Tablets with warfarin clathrate sodium salt in two concentrations and two different particle size distributions were tested as a suitable model for finding the medium and process conditions of dissolution. The dissolution method based on the use of the upper organic layer (1-octanol) and the lower aqueous layer (0.1 mol L–1 HCl) was found suitable and discriminatory for tablets containing active substances in the form of salts of weak acids. The method also reflects physical differences in the quality of used substances.
Keywords
salts of weak acids; warfarin sodium; dissolution method
Hrčak ID:
146067
URI
Publication date:
31.3.2016.
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