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Is Hyperhomocysteinemia Approaching Traditional Risk Factors for Cardiovascular Diseases?

Vesna Lovčić
Mislav Klobučić
Nikolina Bašić-Jukić
Petra Lovčić

Abstract

Hyperhomocysteinemia is an independent risk factor for cardiac, cerebral and peripheral vascular disease as well as for venous thromboembolic disease. Its clinical relevance appears to approach the known, traditional risk factors such as hypercholesterolemia, diabetes mellitus, hypertension, and cigarette smoking. The benefit of homocysteine concentration reduction has been demonstrated in cardiovascular disease. The recommended drug dosage varies among clinical studies, depending on the etiology of hyperhomocysteinemia and on homocysteine and folic acid concentrations in patient serum; however, there is general consensus that folic acid and vitamin B12 are first line treatment. In addition, measurement of homocysteine concentration is advised in patient groups at risk, with an increased daily dietary vitamin intake in these patients.

Keywords

Hyperhomocysteinemia - complications; Hyperhomocysteinemia - physiopathology; Cardiovascular diseases

Hrčak ID:

14088

URI

https://hrcak.srce.hr/14088

Publication date:

1.5.2006.

Article data in other languages: croatian

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