Short communication, Note

Cytogenetic changes in persons occupationally exposed to polychlorinated biphenyls

G. Joksić ; Institut za medicinu rada i radiološku zaštitu »Dr Dragomir Karajović«, Beograd, Srbija
B. Marković ; Institut za medicinu rada i radiološku zaštitu »Dr Dragomir Karajović«, Beograd, Srbija

Abstract

A cytogenetic study performed in a group of workers exposed to polychlorinated biphenyls comprised analysis of structural chromosomal aberrations in the lymphocytes in the first division in vitro, analysis of micronuclei frequency in binuclear lymphoblasts induced by cytochalasin B and analysis of sister chromatid exchanges. The study included 48 exposed workers and 15 controls. In 16 exposed workers increased incidence of unstable chromosomal aberrations (dicentrics, rings and acentrics ) was found, while in 19 no structural chromosomal aberrations could be detected. In 11 workers changes defined as chromosomal and chromatid breaks were noted. This type of change, however, can be evidenced in a non-exposed population as well. In two workers stable chromosomal aberrations were recorded (translocations and inversions). The incidence of micronulei as well as exchange of sister chromatids were elevated in the exposed group of workers compared to controls.

Keywords

chemical mutagens; chromosome aberrations; sister chromatid exchanges; lymphocytes; micronucleus; occupational exposure

Hrčak ID:

147914

URI

https://hrcak.srce.hr/147914

Publication date:

9.6.1992.

Article data in other languages: serbian

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