Review article

Calmodulin levels and the changes in cell physiology

N. Raos ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska
R. Rozgaj ; Institut za medicinska istraživanja i medicinu rada, Zagreb, Hrvatska

Abstract

Calmodulin is a calcium-dependent regulator protein which activates about thirty enzymatic systems. Its intracellular levels, as well as the distribution between cytosolic and membrane fractions, are dependent on chemical (metal ions) and biological agents (hormones, viruses). The changes in levels are particularly pronounced after the cell transformation. The influence of transformation and the effect of chemical/biological agents are discussed separately as are the analytical methods for calmodulin determination. A detailed mechanism of action of chemical and biological agents on calmodulin levels is not yet known.

Keywords

calmodulin biosynthesis; intracellular processes; calcium; malignant transformation; modulatory protein; regulation of calcium level; cell metabolism

Hrčak ID:

148877

URI

https://hrcak.srce.hr/148877

Publication date:

25.3.1992.

Article data in other languages: croatian

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