Original scientific paper
Endemic Glaucoma in the Mune-Brgud Area
Aldo Valković
Ivana Valković-Antić
Asja Valković-Mika
Abstract
In the past century, research into the prevalence of congenital glaucoma among the Mune and Brgud villagers showed that glaucoma was present in 38% of the population. Genealogical studies established the presence of congenital glaucoma through six generations of the villagers. Tradition has it that members of the Šori family have diseased eyes from time immemorial and that other families have through generations been linked to this family, in a repeated circle of conjugal relationships. From the considerable documentation collected, it appears that approximately 50% of the population are genetically linked to the central Šori family. In this group, about half of the offspring show symptoms of this congenital disease. Clinical characteristics of the Mune-Brgud congenital glaucoma are similar to those of the late congenital glaucoma. It is caused by a congenital anomaly of the iridocorneal angle, and is clinically manifested between the age of 10 and 40. It is characterized by goniodysgenesis and high insertion of the iris, remnants of undifferentiated mesodermal embryonic tissue, widening of the trabecular meshwork, decreased aqueous outflow, and regularly present markedly deep anterior chamber. Megalocornea, hypoplasia of the corneal stroma and moderate myopia are present sporadically.
Keywords
Mune-Brgud Glaucoma; Hereditary Glaucoma; Congenital Glaucoma
Hrčak ID:
14370
URI
Publication date:
2.4.2007.
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