Original scientific paper
The role of adrenals in diazinon-induced changes in carbohydrate metabolism in rats
M.A. Matin
; Industrial Toxicology Research Centre, Jl,fahatrna Gandhi Marg, Lucknow, U.P., India
S. Sattar
; Industrial Toxicology Research Centre, Jl,fahatrna Gandhi Marg, Lucknow, U.P., India
K. Husain
; Industrial Toxicology Research Centre, Jl,fahatrna Gandhi Marg, Lucknow, U.P., India
Abstract
Treatment of rats with diazinon (40 mg/kg, i.p.) resulted in hyper-glycaemia and depletion of glycogen from the brain and peripheral tissues two hours after administration. The activities of glycogen phosphorylase and phosphoglucomutase were significantly higher in the brain and liver; that of glucose-6-phosphatase was not altered. The activities of the glycolytic enzymes hexokinase and lactate dehydrogenase were increased only in the brain. The cholinesterase activity in the brain was reduced by treatment with diazinon. The activities of the hepatic gluconeogenic enzymes fructose I.6-diphosphatase and phosphoenolpyruvate carboxykinase were significantly increased. The lactate level was increased in the brain and blood, whereas that of pyruvate was not changed. The activity of glucose-6-phosphate dehydrogenase was not changed to any major extent. Cholesterol and ascorbic acid contents of adrenals were depleted in diazinon-treated animals. The changes were pronounced after intraperitoneal administration of 40 mg/kg diazinon, they were slight but significant after 20 mg/kg, and absent after l0 mg/kg. Hyperglycaemia and changes in carbohydrate metabolism were abolished by adrenalectomy suggesting possible involvement of adrenals.
Keywords
Hrčak ID:
151457
URI
Publication date:
26.3.1991.
Visits: 1.204 *