Original scientific paper

The effect of chlorinated aromatic compounds on isolated hepatocytes

M. Popovič ; Institut za herniju, Prirodoslovno-matematički fakultet, Novi Sad, Srbija
J. Nerudova ; Institut za higijenu i epidemiologiju, Prag, ČSSR
K. Đaković-Švajcer ; Zavod za farmakologiju i toksikologiju Medicinskog fakulteta, Novi Sad, Srbija
S. Pavkov ; Institut za herniju, Prirodoslovno-matematički fakultet, Novi Sad, Srbija

Abstract

The effects of 1,2-dichlorbenzene, 1,2,3,4-tetrachlorbenzene, 1,2,3,5-tetrachlorbenzene, pentachlorbenzene, hexachlorbenzene and Arochlor 1254 on hepatocyte functions were investigated. The viability of hepatocytes as well as glutathione concentration were decreased in all treatments. 1,2- dichlorbenzene diminished the content of cytochrome P-450 and decreased lipoperoxydase and xantinoxydase activities. Under the same conditions the other compounds investigated increased lipoperoxydase and xantinoxydase activities without influencing cytochrome P-450 content. Arochlor 1254 increased the content of cytocrome P-450 in hepatocytes, but had no effect on enzyme activities.

Keywords

Hrčak ID:

152846

URI

https://hrcak.srce.hr/152846

Publication date:

31.1.1989.

Article data in other languages: serbian

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