Review article

DRESS/DIHS: a severe multisystem adverse drug reaction

Andrea Spinčić ; Klinika za dermatovenerologiju,KBC Rijeka, Rijeka
Marija Kaštelan ; Klinika za dermatovenerologiju,KBC Rijeka, Rijeka
Sandra Peternel orcid.org/0000-0001-8590-0451 ; Klinika za dermatovenerologiju,KBC Rijeka, Rijeka

Abstract

The syndrome termed Drug Reaction with Eosinophilia and Systemic Symptoms(DRESS), also known as Drug-Induced Hypersensitivity Syndrome (DIHS) is a severe, lifethreatening,multiorgan adverse drug reaction. It is characterized by an abrupt onset offever and rash, lymphadenopathy, eosinophilia, atypical lymphocytes, liver damage aswell as possible involvement of kidney, lungs, heart, pancreas or other organs. Due to thedelayed onset after the introduction of the culprit drug and a variety of clinicalmanifestations, DRESS/DIHS is frequently unrecognized or its diagnosis is delayed. It ismost commonly caused by anticonvulsants, but various other drugs have been implicatedin its onset. The pathogenesis includes a complex interplay between drugs, reactivation ofherpes viruses and altered immune response. Outcome of the disease varies fromcomplete recovery to permanent systemic complications including development ofautoimmune diseases.

Keywords

drug-induced hypersensitivity syndrome; drug reaction with eosinophilia and systemicsymptoms; Epstein Barr Virus Infections; exanthema; hepatitis; Human herpes virus 6

Hrčak ID:

152973

URI

https://hrcak.srce.hr/152973

Publication date:

1.3.2016.

Article data in other languages: croatian

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