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Acta clinica Croatica, Vol. 54. No. 4., 2015.

Original scientific paper

Migraine, carotid stiffness and genetic polymorphism

Vanja Bašić-Kes ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Miljenka-Jelena Jurašić orcid id orcid.org/0000-0002-1199-6013 ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Iris Zavoreo orcid id orcid.org/0000-0001-9358-1665 ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Lejla Ćorić ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Krešimir Rotim ; University Department of Neurology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; University Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia

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Abstract

Recently migraine has been associated with increased arterial stiffness, procoagulant state, increased incidence of cerebral white matter lesions (WML) and stroke. Our aim was to compare the characteristics of migraineurs to headache free controls regarding their functional carotid ultrasound parameters. Sixty patients (45 women) with migraine (mean age 40.42±10.61 years) were compared with 45 controls (30 women) with no prior history of repeating headache (men age 38.94±5.46 years) using E-tracking software on Alpha 10 ultrasound platform. Student’s t-test was used on statistical analysis with alpha <0.05. All tested carotid vascular parameters were worse in patients with migraine including increased intima-media thickness, greater carotid diameter and carotid diameter change, as well as several arterial stiffness indices. Additionally, patients with migraine had greater incidence of homozygous mutations for procoagulant genes (MTHFR (C677T), PAI-1 and ACE I/D) than expected. Computed tomography and magnetic resonance imaging of the brain showed WML in 11 patients, four of them migraine with aura patients. Since we established increased carotid stiffness and higher frequency of procoagulant gene mutations in migraineurs, we propose prospective ultrasound monitoring in such patients, especially those with detected WML, in order to timely commence more active and specific preventive stroke management strategies.

Keywords

Migraine disorders; Carotid artery diseases; Vascular stiffness; Atherosclerosis; Stroke

Hrčak ID:

154828

URI

https://hrcak.srce.hr/154828

Publication date:

1.12.2015.

Article data in other languages: croatian

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