Acta clinica Croatica, Vol. 54. No. 4., 2015.
Original scientific paper
Gestational diabetes mellitus seems to be associatied with inflammation
Ayla Aktulay
orcid.org/0000-0002-8094-8197
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Yaprak Engin-Ustun
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Mehmet Sahin Ozkan
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Salim Erkaya
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Mustafa Kara
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Oktay Kaymak
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Nuri Danisman
; Department of Obstetrics and Gynecology, Zekai Tahir Burak Women Health Training and Research Hospital, Ankara, Turkey
Abstract
The aim of this study was to investigate whether gestational diabetes mellitus (GDM) is associated with inflammation by comparing serum levels of human chitinase-3-like protein 1 (YKL-40), neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). This case control study included 29 pregnant women with GDM and 29 pregnant women with normal glucose tolerance matched for age (±2 years) and pre-pregnancy body mass index (±2 kg/m2). The
YKL-40/CHI3L1 levels were measured, and NLR and PLR investigated. There were no statistically significant differences in maternal age, gestational age, gravidity and parity. Higher YKL-40 levels were recorded in pregnant women with GDM compared to control subjects (203 (65-300) ng/mL vs. 159.2 (14-290) ng/mL, p=0.007). NLR and PLR were significantly higher in GDM compared with control group. In conclusion, GDM is associated with high levels of YKL-40, NLR and PLR, which indicate inflammatory status.
Keywords
CHI3L1 protein, human; Diabetes, gestational; Leukocyte count; Neutrophils – cytology; Lymphocytes – cytology; Blood platelets – cytology
Hrčak ID:
155436
URI
Publication date:
1.12.2015.
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