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Nanobiomedicine, Vol. 1 No. Godište 2014, 2014.

Original scientific paper

https://doi.org/10.5772/59684

Tryptophan-Assisted Synthesis Reduces Bimetallic Gold/Silver Nanoparticle Cytotoxicity and Improves Biological Activity

Igor O. Shmarakov ; Department of Biochemistry and Biotechnology, Chernivtsi National University, Chernivtsi, Ukraine
Iuliia P. Mukha ; Laboratory of Surface Photonics, Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine
Volodymyr V. Karavan ; Department of Biochemistry and Biotechnology, Chernivtsi National University, Chernivtsi, Ukraine
Olexander Yu. Chunikhin ; A. V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv, Ukraine
Mykhailo M. Marchenko ; Department of Biochemistry and Biotechnology, Chernivtsi National University, Chernivtsi, Ukraine
Natalia P. Smirnova ; Laboratory of Surface Photonics, Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine
Anna M. Eremenko ; Laboratory of Surface Photonics, Institute of Surface Chemistry, NAS of Ukraine, Kyiv, Ukraine

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Abstract

Aiming to reduce the potential in vivo hepato-and nephrotoxicity of Ag/Au bimetallic nanoparticles (NPs) stabilized by sodium dodecyl sulphate (SDS), an approach involving a simultaneous reduction of silver nitrate and tetrachlorauratic acid using tryptophan (Trp) as a reducing/stabilizing agent was applied during NP synthesis. The obtained Ag/Au/Trp NPs (5-15 nm sized) were able to form stable aggregates with an average size of 370-450 nm and were potentially less toxic than Ag/Au/SDS in relation to a mouse model system based on clinical biochemical parameters and oxidative damage product estimation. Ag/Au/Trp NPs were shown to exhibit anticancer activity in relation to a Lewis lung carcinoma model. The data generated from the present study support the fact that the use of tryptophan in NP synthesis is effective in attenuating the potential hepatotoxicity and nephrotoxicity of NPs during their in vivo application.

Keywords

gold; silver; nanoparticles; tryptophan-assisted synthesis; hepatotoxicity; anticancer activity

Hrčak ID:

157638

URI

https://hrcak.srce.hr/157638

Publication date:

1.1.2014.

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