Review article

Endometrial receptivity and window of implantation – secret of concieving?

Mirela Markanović Mišan ; Služba za ginekologiju i porodništvo, Opća bolnica Pula, Pula
Neda Smiljan Severinski ; Zavod za humanu reprodukciju, Klinika za ginekologiju i porodništvo, KBC Rijeka, Rijeka

Abstract

In the process of in vitro fertilisation and embryo transfer, the controlled ovarian stimulation with gonadotrophins leads to the supraphysiological increase of steroid hormone concentration in the follicular and luteal phase of the menstrual cycle. Such altered hormone levels significantly affect the morphological and functional characteristics of the endometrium in the treatment cycle and the activation cascade of the molecular mediators that define the preiod of the endometrial receptivity, known as the „implantation window“. Until today, the number of previous studies have not fully clarify this unique event in the human reproduction. Further researches are needed to reveal new molecular mediators involved in the implantation in order to optimise the IVF/ET procedures and to maximize the effectiveness of infertility treatment in assisted reproduction.

Keywords

embryo implantation; endometrial receptivity; endometrium; fertilisation in vitro; ovarian stimulation; steroids

Hrčak ID:

158503

URI

https://hrcak.srce.hr/158503

Publication date:

1.6.2016.

Article data in other languages: croatian

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