Original scientific paper
CANCER OF THE CERVIX IN IRREGULARY MONITORED AND UNTREATED CYTOLOGIC PRECANCEROSIS
Miodrag Milojković
Mirjana Rubin
Abstract
The aim. To estimate the importance of some risk factors that influence the time period between the precancer¬ and cancer occurrence of the cervix. Methods. Retrospective study of 52 women with cervical cancer which developed due to the irregularly monitored and untreated cytological precancer, in the period from January 1st, 1991 to June 30th, 2001. In this statistical analysis we used analysis of variance (ANOVA), t-test, and Spearman’s rank correlation coefficient with Spearman’s nonparametric test for rank correlation. Results. At the time of the first HSIL cytological finding, patients were 37.6 years old, with first LSIL 39.6 and with ASCUS/AGCUS 52.9 years old on the average. The patients previously having HSIL were not cytologically followed for 77.5 months, with LSIL for 52.8 months and with ASCUS/AGCUS 36.3 months on the average. Cancer of the cervix was detected after 93.2 months on the average after the first HSIL cytological results had been obtained. Cervical cancer was discovered after 76.0 months on the average after the first LSIL cytological results, and after 47.9 months on the average after the first ASCUS/AGCUS cytological results had been obtained. The mean age of the patients with cervical cancer after HSIL was 45.4, after LSIL 46.0, and after ASCUS/AGCUS 56.9 years. Conclusion. It may be said that besides other risk factors, the time period, between the precancer and cervical cancer occurrence in studied women, is to great extent influenced by the age of the patients, at the time when precancer was cytologicaly diagnosed.
Keywords
cytological precancer; cervical cancer; monitoring; patients age
Hrčak ID:
15515
URI
Publication date:
1.3.2003.
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