Professional paper
INFLUENCE OF THE HORMONAL REPLACEMENT THERAPY ON MAMMOGRAPHIC CHANGES
Višnja Matković
Abstract
Objective. To date is not clear how often mammography should be performed in women on hormonal replacement therapy (HRT). We decided to make a retrograde analysis of mammograms in women on HRT in order to identify women at risk of breast cancer, who require more frequent follow-up examinations. Material and methods. The study included 79 women on HRT. All of them have performed mammography before introducing HRT. The patients were randomly assigned in two groups: in 39 patients clinical and mammographic follow-up was repeated after 1 year and in 40 patients after 2 years. The mammograms were classified according to Wolfe’s classification. Several parameters which were expected to potentially influence the risk of breast cancer were observed. These parameters include: personal history, family history, number of deliveries, lactation, earlier hormonal therapy and type of HRT. Results. The younger women on average are more often on progestin therapy while older women use a combined hormonal therapy. The type of HRT has not been observed to have any influence on mammograms. In both groups mammogram changes were observed in similar proportions of patients, e.g. no significant difference was observed. The follow-up mammogram was worse in 5% of the women on HRT during 1 year and 10% in the women on HRT during 2 years. Conclusion. The short-term use of HRT does not appear to have any influence on mammogram and it could be repeated every two years in women on HRT.
Keywords
breast cancer; hormonal replacement therapy; mammography
Hrčak ID:
15583
URI
Publication date:
1.6.2004.
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