Original scientific paper

THE DYNAMICS OF HAEMOSTATIC PARAMETERS IN ACUTE PSYCHOTIC PATIENTS: A ONE-YEAR PROSPECTIVE STUDY

Jiří Masopust Masopust ; Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic
Radovan Malý ; Department of Internal Medicine, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic
Ctirad Andrýs ; Institute of Clinical Immunology and Allergology, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic
Martin Vališ ; Department of Emergency Medicine, University Hospital Hradec Králové, Czech Republic
Jan Bažant ; Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic
Ladislav Hosák ; Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Czech Republic, Department of Psychiatry, University of Ostrava, Faculty of Medicine, and University Hospital Ostrava, C

Abstract

Background: The primary goal of the present study was to replicate our previous finding of increased coagulation and
thrombocytes activity in drug-naïve psychotic patients in comparison with healthy controls and ascertain whether the blood levels of
thrombogenesis markers further increase over the course of a consecutive one-year antipsychotic treatment.
Subjects and methods: We investigated the plasma levels of markers indicating activation of coagulation (D-dimers and Factor
VIII) and platelets (soluble P-selectin, sP-selectin) in an antipsychotic-naive group of nineteen men and seventeen women with acute
psychosis (age 28.1±8.0 years, body mass index 22.6±4.2), and thirty-seven healthy volunteers matched for age, gender and body
mass index. In the patient group, we repeated these assessments after three months and again after one year of antipsychotic
treatment.
Results: D-dimers (median 0.38 versus 0.19 mg/l; p=0.00008), factor VIII (median 141.5% versus 110%; p=0.02) and sPselectin
(median 183.6 versus 112.4 ng/ml; p=0.00005) plasma levels were significantly increased in the group of patients with acute
psychosis prior to treatment compared with healthy volunteers. The plasma levels of sP-selectin varied significantly (p=0.016) in the
course of the one-year antipsychotic treatment, mainly between 3 and 6 months after start of therapy. The plasma levels of D-dimers
and factor VIII did not change significantly, D-dimers remained elevated in contrast to the healthy controls.
Conclusions: Patients with acute psychosis had increased levels of markers of thrombogenesis in comparison to the healthy
volunteers. The haemostatic parameters also remained elevated during the one-year antipsychotic treatment.

Keywords

psychosis – thromboembolism - markers of thrombogenesis – coagulation - antipsychotic treatment

Hrčak ID:

161169

URI

https://hrcak.srce.hr/161169

Publication date:

10.6.2013.

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