Review article

https://doi.org/10.21860/52;3_272

Glomerular diseases: a review of the literature and of the epidemiology of biopsy proven glomerular diseases diagnosed in KBC Rijeka

Gordana Đorđević orcid.org/0000-0002-2010-6203 ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Sanja Štifter ; Zavod za patologiju i patološku anatomiju, Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Barbara Borovac ; Medicinski fakultet Sveučilišta u Rijeci, Rijeka
Massimo Bembić ; Medicinski fakultet Sveučilišta u Rijeci, Rijeka

Abstract

Glomerular disease could be caused by hemodynamic changes, infections, improper immune response, hereditary metabolic disorders, by the action of toxic substances, and sometimes the cause remains hidden. The basic science and translational research combined with clinical surveys, have improved our understanding of the etiopathogenesis of these diseases. This new knowledge has led to change of the existing classification of glomerulopathies. Advances in knowledge of molecularpathways of the cell cycle or the discovery of new genetic defects contributed to the creation of more patient oriented therapeutic approaches and better quality of life in patients with renal impairment . The aim of this review is to briefly discuss the general principles in the pathology of glomerular injury and to consider some of the recent researches about podocitopathies; membranous glomerulopathy (MG); ANCA vasculitis; C3 glomerulopathy and the role of complement in glomerular damage. Review also demonstrates the value of a kidney biopsy as an essential diagnostic and prognostic, as well as epidemiological and research tool.

Keywords

biopsy; complement activation; Fluorescent Antibody Technique; genotype

Hrčak ID:

163953

URI

https://hrcak.srce.hr/163953

Publication date:

1.9.2016.

Article data in other languages: croatian

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