Professional paper
Quantitative determination of porphyrin in red blood cells in persons exposed to lead
A. Kansky
; Dermatološka klinika Medicinskog fakulteta i Dispanzer za profesionalne bolesti ZZV, Ljubljana
Blaga Kramberger
; Dermatološka klinika Medicinskog fakulteta i Dispanzer za profesionalne bolesti ZZV, Ljubljana
H. Kosler
; Dermatološka klinika Medicinskog fakulteta i Dispanzer za profesionalne bolesti ZZV, Ljubljana
Abstract
In 30 persons exposed to lead and in 30 healthy persons the following quantitative analyses were carried out: coproporphyrin (KP) and protoporphyrin (PP) in red blood cells and KP, uroporphyrin (UP), delta-aminolevulinic acid (ALA) and porphobilinogen (PBG) in urine. According to the concentration of PP in red blood cells, the persons examined were divided into two groups. Group B comprised 14 persons in which the PP concentration in 100 ml red blood cells did not exceed 18 µg, which is the upper normal limit. All were free from clinical symptoms. The mean values for KP in red blood cells as well as for UP, ALA and PBG in urine were well within normal limits. Only the mean value of KP in urine was increased. Out of 16 persons included in group A four displayed signs of lead intoxication and 12 were symptom free. The following mean values were found: PP 82,9 and KP 6,8 µg in 100 ml red blood cells, ALA 3,7 and PBG 0,24 mg in 100 ml urine, KP 171,5 µg and UP 26,5 µg in 1000 ml urine. All the mean concentrations in this group except the PBG were significantly increased as compared to those in healthy persons. In the four lead intoxicated persons the PBG concentration in urine ranged from 0,32 to 0,57 mg in 100 ml urine, what exceeds the normal values (up to 0,32 mg). According to our experience the analysis of PP in red blood cells can be a useful test in the medical control of lead exposed persons.
Keywords
Hrčak ID:
168786
URI
Publication date:
18.9.1972.
Visits: 1.352 *