Liječnički vjesnik, Vol. 133 No. 3-4, 2011.
Professional paper
NONSTEROIDAL ANTIRHEUMATICS AND HYPERTENSION
Krešimir Galešić
Bojan Jelaković
Abstract
Nonsteroidal anti-inflammatory drugs (NSAID) are the most common prescribed drugs in clinical medicine (4–9% of all prescriptions), and their side-effects are very common. These drugs, the older group, nonselective ciclooxigenase inibitors (inhibitors of COX-1 and COX-2), may increase blood pressure and cardiovascular risk. Many studies have shown that NSAID could increase blood pressure for 5–10 mmHg. The use of NSAID is common and their side effects to increase blood pressure have a large impact on the public health. The main mechanism of the increased blood pressure by NSAID is blockage of prostaglandin synthesis. The results of blockage of prostaglandin synthesis are sodium and fluid retention. NSAID may increase blood pressure in normotensive and hypertensive persons. Indomethacin, naproxen, and other NSAID increase the blood pressure in patients treated with b-blockers, diuretics, metildopa, ACE-inhibitors and combination of various antihipertensive drugs, but there is no increase of blood pressure in patients treated with calcium blockers. In many studies, aspirin did not increase the blood pressure. The new group of NSAID, coxibes, selective ciclooxigenase inibitors (inhibitors of COX-2) could increase the blood pressure like older generation of NSAID.
Keywords
: Anti-inflammatory agents, non-steroidal – adverse effects, pharmacology; Blood pressure – drug effects; Hypertension – chemically induced
Hrčak ID:
171663
URI
Publication date:
28.4.2011.
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