Original scientific paper

https://doi.org/10.1515/acph-2017-0011

Quantitative analysis of povidone-iodine thin films by X-ray photoelectron spectroscopy and their physicochemical properties

ANONGTIP SA ; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
SOMCHAI SAWATDEE ; Drug and Cosmetic (Research and Development Unit), School of Pharmacy, Walailak University, Thasala, Nakhon Si Thammarat 80161, Thailand
NARUBODEE PHADOONGSOMBUT ; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
WILAIPORN BUATONG ; Nanotec-PSU Excellence Center on Drug Delivery System, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
TITPAWAN NAKPENG ; Nanotec-PSU Excellence Center on Drug Delivery System, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
RUTTHAPOL SRITHARADOL ; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand
TEERAPOL SRICHANA ; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand; Nanotec-PSU Excellence Center on Drug Delivery System, Faculty of Pharmaceutical Sciences, Prince of Songkla Univ

Abstract

In this study, povidone-iodine (PVP-I) has been formulated as a topical spray to produce a thin film for the controlled release of I2. By means of experimental design, 27 formulations containing glycerol, ethanol, PEG 400, copovidone and HFA 134a as a propellant were prepared. The pH values of all formulations were in the range of 6–7. The viscosity was within the range of 11.9–85.9 mPas. The surface tensions were 20.3 to 24.6 mN m–1 and the contact angles were between 19.3 and 38.7. The assays for the iodine contents were within acceptable range (80–120 %). X-ray photoelectron spectroscopy analysis revealed the ionized form of iodine was much higher than the unionized form. The MIC and MBC values of the PVP-I sprays against Staphylococcus aureus, S. epidermidis and Pseudomonas aeruginosa were higher than that of commercial PVP-I solution. The cytotoxicity study confirmed that the PVP-I spray had lower toxic effects on keratinocytes and fibroblasts compared to the commercial PVP-I solution. The formulation containing 59 % ethanol, 18 % copovidone and 12 % PEG 400 showed good antibacterial activity.

Keywords

povidone-iodine; topical spray; bioactivity; cytotoxicity; X-ray photoelectron spectroscopy

Hrčak ID:

172761

URI

https://hrcak.srce.hr/172761

Publication date:

30.6.2017.

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