Original scientific paper

Synthesis and Antibacterial Effect of Derivatives of 5-(3,4,5-Trimethoxy benzyl)- pyrimidine, -Tetrahydropyrimidine,-Hexahydropyrimidine and -Hydantoin

Nedjeljko Kujundžić ; Pliva Research Institute, Zagreb, Croatia, Yugoslavia
Krunoslav Kovačević ; Pliva Research Institute, Zagreb, Croatia, Yugoslavia
Miroslav Jakovina ; Pliva Research Institute, Zagreb, Croatia, Yugoslavia
Berislav Glunčić ; Pliva Research Institute, Zagreb, Croatia, Yugoslavia

Abstract

Pyrimidine derivatives I (R\ R2, R3 = Cl, Cl, Cl; Cl, OCHa, Cl;
OCH3, OCH3, Cl; OCHa, OCH3, OCHa; NH2, OCHa, Cl; OCHa, NH2,
OCHa; NH2, H, H; H, NH2, H; H, OH, OH; H, Cl, Cl; H, NH2, NH2
resp.), hexahydropyrimidine-4,6-diones II and III (R4= CH3, C2H5,
C3H7, CH2CH = CH2, C4H9), tetrahydropyrimidine-4,6-diones IV (R4
the same) and hydantoins V (R4 the same) were synthesized.
In vitro antibacterial activity of these compounds was tested In vitro antibacterial activity of these compounds was tested
against some bacteria strains and compared with that of the well
known bacteriostatic trimethoprim VI.
The activity of compound I (R! = H, R2 = R3 = OH) was
higher than that of trimethoprim against Sarcina lutea ATCC 9341,
Klebsiella pneumoniae ATCC 10031 and Pseudomonas aerugiosa
NCTC 10490 while the compounds of group IV acted also against
Corynebacterium xerosis NCTC 9755, E. coli ATCC 10536 and Shigella
flexneri.

Keywords

Hrčak ID:

175881

URI

https://hrcak.srce.hr/175881

Publication date:

28.4.1988.

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