Original scientific paper

Structure-Activity Relationships in Odor Perception of Drimane Derivatives

Gunther Ohloff ; Firmenich SA, Research Laboratories, CH-1211, Geneva 8
Wolfgang Giersch ; Firmenich SA, Research Laboratories, CH-1211, Geneva 8

Abstract

The woody, ambergris-Iike odor of trans-decalone derivatives of type 5 increases with the introduction of equatorial alkyl substituents in the C(9)-positionand decreases drastically in the corresponding 9-epi derivatives. Complete stereocontrol of odor perception has been observed for the diastereoisomers of y-bicyclohomofarnesal 1 and 2. A similar tendency in odor perception has been recognized in substituted alcohols of type 12. The sandalwood- like ambergris note found in Polywood'": (14) disappeared in corresponding alkyl substituted acetates. The molecular basis of the 'steroid-type' scent of some esters of type 39 was hitherto unknown.

Keywords

Hrčak ID:

178039

URI

https://hrcak.srce.hr/178039

Publication date:

6.3.1986.

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