Original scientific paper

Biosynthesis of the Cytochalasans. The Mode of Incorporation of L-Methionine into the Cytochalasins A and B, Protophomin and Proxiphomin

Ronald Wyss ; Institut fur Organische Chemie der Universitat, St. Johannsring 19, CH-4056 Basel, Switzerland
Christoph Tamm ; Institut fur Organische Chemie der Universitat, St. Johannsring 19, CH-4056 Basel, Switzerland

Abstract

Incorporation of [l3C,2H3-CHs]-L-methionine into cytochala-: sin A (I), cytochalasin B (II), proxiphomin (III) and protophomin (IV) by Phoma exiqua var. exiqua demonstrated that the two C-methylations occur with retention of all three H-atoms of the methyl group. Conclusions are drawn concerning the stage of the methylation reaction during the biogenetic pathway. On the basis of the results amore detailed general scheme of the cytochalasan biogenesis is proposed,

Keywords

Hrčak ID:

178043

URI

https://hrcak.srce.hr/178043

Publication date:

6.3.1986.

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