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Original scientific paper

Reactivation of phosphorylcholinesterase in the rat's cerebral cortex following parenteral application of pralidoxime (PAM - 2) and toxogonine

D. Anđewlković ; lnstitut z a farmahologiju i toksikologiju Medicinskog fakulteta, Beograd
M. Milošević ; lnstitut z a farmahologiju i toksikologiju Medicinskog fakulteta, Beograd


Full text: serbian pdf 8.087 Kb

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Abstract

From the recently proved selective affinity of pralidoxime (PAM-2) to certain areas of the brain it has been assumed that only .by measuring the enzymic activity of brain sections and not homogenates reactivation of the cholinesterase inhibited by organophosphorus compounds can be proved. A series of experiments performed on·paraoxone poisoned rats treated with pralidoxime and toxogonine (LüH 6) respectively showed a considerably higher cholinesterase activity in the cerebral cortex than in animals which received only the inhibitor. Contradictory results of various authors op. the reactivating property of pralidoxime in organophosphate poisoning are discussed and explained.

Keywords

Hrčak ID:

178652

URI

https://hrcak.srce.hr/178652

Publication date:

17.6.1966.

Article data in other languages: serbian

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